INVESTIGATIONS OF THE BINDING PARAMETRES OF THE INTERACTION OF N'-FERROCENYLMETHYL-N'-PHENYLACETO- AND PROPIONOHYDRAZIDE WITH DNA
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Date
2019-05-01
Journal Title
Journal ISSN
Volume Title
Publisher
university of eloued -جامعة الوادي
Abstract
Herein we describe the determination of binding parameters of the interaction of N'-
ferrocenylmethyl-N'-phenylacetohydrazide (FcA) and N'-ferrocenylmethyl-N'-phenylpropionohydrazide (FcP) derivatives with chicken blood double-stranded DNA (cb-ds DNA)
in phosphate buffer (PB) solution at physiological pH 7.2 by electronic spectroscopy and
molecular docking calculations. The results indicated that both FcA and FcP bind DNA in
groove binding mode, values of binding constants and binding free energy obtained from
electronic spectroscopy measurements and molecular docking calculations were in good
agreement
Description
article
Keywords
DNA, interaction, electronic spectroscopy, molecular docking
Citation
H. Mouada, T. Lanez*, E. Lanez, INVESTIGATIONS OF THE BINDING PARAMETRES OF THE INTERACTION OF N'-FERROCENYLMETHYL-N'-PHENYLACETO- AND PROPIONOHYDRAZIDE WITH DNA. Journal of Fundamental and sciences. vol.11, no 2. May 2019. Faculty of exact sciences. university of el oued. [visited in 01/05/2019]. available from [[email protected]]