JFAS_Vol 11 N 02

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    MOLECULAR DOKING AND ADMET STUDIES OF AMINO-PYRIMIDINE DERIVATIES AS MYCOBACTERIUM TUBERCULOSIS SER/THR PROTEIN KINASES B INHIBITORS
    (university of eloued -جامعة الوادي, 2019-05-01) Khamouli1, S; Belaidi, S; Lanez2, T
    We used the molecular docking method with Molegro software and we calculate ADME-T properties using Marvin Sketch and preADMET. The 29 amino-pyrimidines ligands were examined for docking studies with PknB (PDB Code: 2FUM).The Moldock score of the best three ligands L9, L12 and L21 are-161.475, -152.003 and-143.359 Kcal/Mol. These percentage shows that these candidature ligands have high binding energy percentage than the native MIX ligand. The ligand L21 has the human intestinal absorption (HIA), Caco-2 cell permeability, and plasma protein binding values of 85.48, 6.312 (nm/Sec.) and 93.097% respectively, which are comparable to MIX and the other ligands L9, L12. This computational study helped to prove that the ligand L21 have the ability to kill the Mycobacterium tuberculosis by inhibiting the expression of protein kinase B.
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    SIMULATION OF THE THERMOMECHANICAL LOADS AND CRACKPROPAGATION OF DIFFERENT DIESEL ENGINEPISTON CROWN MATERIALS BY THE XFEM METHOD
    (university of eloued -جامعة الوادي, 2019-05-01) Gherbi, M.T; Nour, A; Far3, A; Aguib, S; Djedid, T; Settet, A.T
    This study concerns the dynamic behavior of the piston of a Deutz F8L413 diesel engine. The objective is to simulate by the extended finite element method (XFEM) the thermomechanical behavior of different piston materials.This study is conducted to evaluate the applied thermal loads and pressure at the end of compression. From a numerical simulation, the stresses acting on the structure and the behavior of the cracked material piston, governed by its global elastic behavior and quantified by the stress intensity factor are determined
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    COMPUTATION CHEZY’S COEFFICIENT IN A SEMI-ELLIPTICAL PIPE
    (university of eloued -جامعة الوادي, 2019-05-01) Beboukha, Y; Lakehal, M; Remaoun, M; Remaoun, M; Achour, B
    In the hydraulic field, the Chezy’sflow resistance coefficientin canals and pipes is often chosen arbitrarily. This value is tabulated independently of the depth of the flow or hydraulic radius and even less of the Reynolds number. This coefficient is usually influenced by a number of parameters that mustbedefinedand considered. The objective of this study is to examine, on the one hand, the variation of the Chezy’sflow resistance coefficient for a semi-ellipticalpipe under the hypothesis of an uniform flow with free surface, and to determine on the other hand, the expressions which govern them. Further, it must search expression forChezy’swith consideration of the geometric characteristics of the pipe and hydraulic flow. This study is based on the rough model method (RMM).
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    REAL TIME IMPLEMENTATION OFNONLINEAR PI CONTROLLER FOR THE INDUCTION MACHINE CONTROL
    (university of eloued -جامعة الوادي, 2019-05-01) Habbab, M; Hazzab, A; Alalei, A
    n this paper a nonlinear PI (NPI) controller are proposed and compared with the conventional linear fixed-gain PI controller to improve the overall performance of the system by incorporating a sector-bounded nonlinear gain in cascade with a conventional PI control architecture. The proposed controller has implemented for a 1.5-kW three-Phase Induction Motor are completely carried out using a dSPACE DS1104 digital signal processor (DSP) based real-time data acquisition control (DAC) system, and MATLAB/Simulink environment. Digital experimental results are presented to show the improvement in performance of the proposed algorithm
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    Journal of Fundamental and Applied Sciencesis licensed under aCreative Commons Attribution-NonCommercial 4.0 International License.Libraries Resource Directory. We are listed underResearch Associationscategory.IN VITRO ANTIBACTERIAL ACTIVITY OF CHLOROFORM, ETHYL ACETATE AND BUTANOL EXTRACTS OF LEAVES OF CITRULLUS LANATUS VAR. CRIMSON SWEET GROWN IN THE REGION OF OUARGLA, ALGERIA
    (university of eloued -جامعة الوادي, 2019-05-01) Bennouna, A; B, B; Dendougui, H
    We are always trying to discover antibiotics, of natural origin, the most effective. For this purpose, our work is devoted to the evaluation of the antibacterial activity of the chloroformic, ethyl acetate and butanolic extracts of the leaves of citrulluslanatuscrimson sweet variety cultivated in the region of Ouargla. This activity was tested against microorganisms derived from the reference strains gram positive (Staphylococcus aureus and Streptococcus sp) and gram negative (Escherichia coli and Pseudomonas aeuruginosa). All extracts showed a remarkable sensitivity against bacteria by giving inhibition diameters varying between 12 and 26 mm. The evaluation of the minimum concentration of inhibition (MIC) led to the valuesbetween 40 and 75 μg/ml. From the results obtained, we can conclude that the leaves of this plant have a good antibacterial activity against certain microorganisms
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    HIGH SENSITIVITY DETECTION OF THE STATOR SHORT-CIRCUIT FAULTS IN INDUCTION MOTOR USING HILBERT PARK’S VECTOR PRODUCT
    (university of eloued -جامعة الوادي, 2019-05-01) Allal, A; Chetate, B
    In this paper, a new approach for induction motor diagnosis, which called: Hilbert Park’s Vector Product Approach (HPVPA), is proposed, this processes offers unprecedented a high sensitivity in case of stator faults. In order to highlight the effectiveness of this method, this paper included with an important comparison between the proposed method and the proposed techniques in the recently research works; such as: Motor Square Current Signature Analysis (MSCSA), Park's Vector Square Modulus (PVSM), Park’s Vector Product Approach (PVPA), Park-Hilbert “P-H” ( PVSMP-H) and the classical method: Motor Current Signature Analysis (MCSA). The proposed approach bases on three essential steps: firstly, the Hilbert transform of the three phases currents will be aplicated, and then their instantaneous amplitudes will be extracted. Secondly,their current Park's vector components will be reduced. Finally, we apply the mathematical product of its two current Park’s vector components is applicated
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    GREEN SYNTHESIS OF IRON NANOPARTICULES USING LEAF EXTRACTFROMPHOENIX DACTYLIFERA. L
    (university of eloued -جامعة الوادي, 2019-05-01) Laouini, S.E
    In this research paper, the synthesis of ironnanoparticlesby a simple and eco-friendly methodusing extract leaves fromPhoenix DactyliferaL withdifferentconcentration ofFeCl3wasinvestigated. Thenanoparticlessynthesiswere characterizedusing adifferentmethodsUv-Visiblespectrophotometer, infraredspectroscopyandXRD. Thefirstresult was found forthe size ofnanoparticlesandrelationshipwiththeconcentration ofFeCl3, the highconcentration (0.03 M) product the nanoparticleswith size 2.3 nmand thelowconcentrationproduct thenanoparticles with size 22.16 nm. The FTIR analysisconfirmedthe biosynthesisofnanoparticleswith absorption from 500 to 800 cm-1. The crystallinestructureofNPswasconfirmed by X-ray diffraction (XRD) analysis. The antioxidant properties of the obtainedbiomaterial were assessedin vitro, using theDPPH and PPM test.The Fe3O4showed highantioxidant activity againstthemto test. Theresultssuggest thatPhoenix DactyliferaLextractassisted tosynthesisNPs present promising antioxidantcapacityand hence haveanimportant interestinthe development of therapeutic agents against oxidative tissue injuries.
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    COMPARATIVE STUDY AND ANALYSIS OF PERFORMANCE REFRIGERATIONSYSTEMDRIVEN BY DIFFERENT ENERGYSOURCES
    (university of eloued -جامعة الوادي, 2019-05-01) Guermit, T; Settou2, N
    The present work concerns a study on mechanical compression refrigeration machines thatbased on the electric compressor, and absorption machine, were this work is focused onchoosing natural gas as a direct source in the refrigeration space; this logic was presentgeneral thermodynamic calculations of the two machines. The results show that quite goodvalues of the coefficient of performance of the new configuration of the absorptionrefrigeration machine and the study of the cost of each one, we can consider it encouragingfor the development of this device, which promises to bean alternative one hand to eliminatethe pressure in the electricity sector, and promises to be quite powerful economic and energypointof viewand side environment
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    STUDY OF THE PHYSICO-CHEMICAL PARAMETERS CHARACTERIZING THE QUALITY OF EL’MENIA LAKE. ALGERIA
    (university of eloued -جامعة الوادي, 2019-05-01) Benbitour1, S; Babaamer2, Z
    The objective of this work is to evaluate the physico-chemical quality of El-Menia Lake, experiencing the effect of the discharges of waste water in this lake. The results of physico-chemical study show that El-Menia Lake is characterized by a high conductivity and very hard quality with remarkable pollution in most points. Concerning the concentrations of heavy metal elements we found a high concentration in some metals like the lead, cadmium, cobalt and some metals less than standard value of surface water
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    DETERMINATION OF SPONTANEOUS EMISSION RATE AND CARRIER RECOMBINATIONCHANNELS IN GaInAsSb/AlGaAsSbMULTIPLE QUANTUM WELL LASER DIODES EMITTING NEAR 2.3 μm
    (university of eloued -جامعة الوادي, 2019-05-01) Gadedjisso-Tossou, K.S; Dzagli, M.M; Mohou, M.A; Rouillard, Y
    In this paper, Amplified spontaneous emission spectra is used to extract the gain and internal loss of 2.3 μm narrow ridge-waveguide GaInAsSb-AlGaAsSb quantum well laser diodes by Cassidy’s method. The spontaneous emission intensity was extracted using the average value of the amplified spontaneous emission intensity. The dependence of the integrated spontaneous emission intensity on injection current has been studied. The results show that the current is dominated by radiative recombination at this emission wavelength.
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    SYSTEM FOR PREDICTING DISCHEARGES OVER THE HIGH WATER PERIOD THROUGH THECLASSIFICATION TECHNIQUES DATA: CASE OF THE GAMBIA RIVER BASIN OF MAKO
    (university of eloued -جامعة الوادي, 2019-05-01) Faye, C
    This article examines the trend of flow during the high water period(from July till November) in the basin of Gambiameasured at the Mako station of over 2004-2013 period. Methodology consisted at first in calculation and in standardizationof data by the method of z-score of some statistical parameters (average, maximum, minimum, range and standard deviation). Obtained series were afterward submitted to classifications techniques such as k-means clustering and Agglomerative Hierarchical Clustering (AHC) of Time Series Data Mining to cluster and discover the discharge patterns in terms of the autoregressive model.. From these methods, a forecast modelhas been developed for the discharge process on average over these years. This study presents basin flow dynamics in high water periodfrom Time Series Data Mining technique
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    INVESTIGATIONS OF THE BINDING PARAMETRES OF THE INTERACTION OF N'-FERROCENYLMETHYL-N'-PHENYLACETO- AND PROPIONOHYDRAZIDE WITH DNA
    (university of eloued -جامعة الوادي, 2019-05-01) Mouada, H; Lanez, T; Lanez, E
    Herein we describe the determination of binding parameters of the interaction of N'- ferrocenylmethyl-N'-phenylacetohydrazide (FcA) and N'-ferrocenylmethyl-N'-phenylpropionohydrazide (FcP) derivatives with chicken blood double-stranded DNA (cb-ds DNA) in phosphate buffer (PB) solution at physiological pH 7.2 by electronic spectroscopy and molecular docking calculations. The results indicated that both FcA and FcP bind DNA in groove binding mode, values of binding constants and binding free energy obtained from electronic spectroscopy measurements and molecular docking calculations were in good agreement
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    STRUCTURAL STUDY AND THE EFFECT OF IONIC SIZE OF THE SYSTEMS (Gd1-x LuX) 3Al5 O12 DOPED ERBIUM.
    (university of eloued -جامعة الوادي, 2019-05-01) Lanez, I; Rekik, B; Derbal, M; Chaib, A
    The structure of cubicGarnetsmulti-componentsbased on Gadolinium (GAG)undopedor doped rare earth,stabilized by Lanthanide as Lutetium,which has weak ionic radiusrecently attracts much attention to obtain the phasesthermodynamically stables.In this work, we have chosento studythe development of compositions of type (Gd1 -x Lux) 3Al5O12(x = 0, 2 -0, 3)doped 2and 5 at %Er+3. The polycrystalline powders were prepared by reactionsolid statemethod. DRXanalyses on thesesynthesized powders confirmed the results of the phases of GdAlO3perovskiteandGd3Al5O12garnet dueto the highercontent of gadoliniumstabilized by Lutetium. FTIRanalyses have shown the active vibrations modes associated on the specifics absorption bandsof M –O (M: metallic elements Gd and Lu or Al).The optical analyzes carried out by the photoluminescence spectroscopy which it study the transitions of Erbium (Er3+)as doping elements in elaborated samples is of great optical importance
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    CROWD DYNAMICS ANALISYS: SIMULATING HETEREOGENEOUS CROWDS WITH PANIC EFFECT STOCHASTICS BEHAVIOUR
    (university of eloued -جامعة الوادي, 2019-05-01) Tan, Z; Othman, W.A.F.W; Wahab, A.A.A; Alhady, S.S.N
    In a crowd, where the density might reach one person per square meter and above, the mass of individuals moves in a way that may potentially induce panic amongst individuals, or hazards of personal injuries, from slight to fatal. A computer simulation is implemented and conducted in order to study and analyze the dynamics and behavior of crowds, both at micro- and macro-levels. The simulation is comprised of multiple arenas with different layouts, as well as different compositions of heterogeneous agent behavior. The simulations are observed to conform to established results on a localized scale, and the statistical data shows no significant increase in total evacuation time with increasing composition of non-interactive, path-finding agents amongst flocking agents.
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    INFLUENCE OF ARID CLIMATE ON THE CONTENTOF THE PLANT "CYNODON DACTYLON (L) PERS" IN FLAVONOÏDS
    (university of eloued -جامعة الوادي, 2019-05-01) Benzahi, R; Benzahi1, K; Dadamoussa, B; Moussaoui, Y; Labed, B; Mokadem1, K
    During its evolution, plants have developed substances (called here active principles) with different functions, this can be a defense against parasitesor other aggressors (micro-organisms), a technique to prevent the growth of other nearby plants and thus ensure good nutrition, as a means of growth or renewal of the species.The concentration of active principlesof a plant varies according to the age of the plant, the season, the climate and the environment in general (drought, pollution, etc).This is why it is important to know the best time of the year, and even of the day (morning, day, evening, night) to harvest the plant.According to our study, it was found that the plant Cynodon dactylon "L" Pers has a differentcomposition and content of flavonoids between two periods.
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    EXPERIMENTAL STUDY OF DUST ACCUMULATION EFFECT ON PHOTOVOLTAIQUE SOLAR MODULE PERFORMANCE IN ZIGUINCHOR, SENEGAL
    (university of eloued -جامعة الوادي, 2019-05-01) Sidibba, A; Ndiaye, D; Kobor2, D; Menny3, E
    The present work focuses on a study of dust accumulation effect on a photovoltaic solar module performance in the environment of Ziguinchor, Senegal. Two polycrystalline photovoltaic modules 0.75 W were exposed to the outdoor environment on rooftop of the Chemistry and Materials Physics Laboratory (LCPM) at Assane Seck University, Ziguinchor, Senegal (12 ° 34 N, 16 ° 16 E ). The two PV panels were exposed for 70 days to the outdoor environment from March 20, 2018 until May 30, 2018, where, the dusty PV panel was left without cleaning for natural dust accumulation, and the reference PV panel was cleaned daily. The results showed that after 70 days of outdoor exposure without rain, the dust surface density ranged from 0 (g/m2 ) at the beginning to 13.84 (g/m2 ) at the end of the experiment; which resulted in a 92.3 (%) reduction in the reference module efficiency
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    STATISTICAL AND HYDROCHEMICAL CLASSIFICATION OF UNDERGROUND WATERS IN A MULTI-LAYER AQUIFER SYSTEM IN AN ARID ZONE :APPLICATION TO CHOTT EL GHARBI BASIN (EXTREME WEST OF ALGERIA)
    (university of eloued -جامعة الوادي, 2019-05-01) Boudjema1, A; Guettaia, S; Brinis, N
    The studied area, so called Chott El Gharbi shelters a multilayer aquifer system. The hydro-chemical tool shows that the results of the groundwater analyzes of the aquifer system of the Chott El Gharbi region revealed that they are sulphated-calcium and magnesian. Water infiltrated at the Bajo-Bathonian and Mio-Plio-Quaternary carbonate formations is enriched with HCO3-and SiO2 along its underground route. Also, the presence of a Triassic evaporitic formation or the Cenomano-Turonian argilo-gypsum formation enriches these waters with SO42-, Cl-, K+, Mg2+, Na+ and Ca2+.Thermodynamics has shown that these waters are under saturated evaporitic elements, which gives them a greater power of dissolution than that of carbonates which are in equilibrium or sometimes even supersaturated and tend to precipitate.
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    FRACTURE TOUGHNESS ASSESSMENT OF DEEP WELL ROCK USING CCNBDAND SCB TEST PROTOCOLS
    (university of eloued -جامعة الوادي, 2019-05-01) Ghomesheh, P. K; Hosseini, A; Fathi, A
    Fracture mechanicsis widely deployedin stone fracture modeling, digging with hydraulic, and dynamic fracture techniquesfor assessing the effects of rock fracture mechanical properties on different hydraulic fracture digging process. To get a better insight aboutthe process, testing the actual rock samples can beextremely imperative. This study, indeed, attempts to evaluate the fracture toughness of actual rock samples using two different test protocols, i.e.,Cracked Chevron Notched Brazilian Disc (CCNBD) and Semi-Circular Bend (SCB). The results indicate thatsimilar behavior is observed for the samples underthe two tests. However,due to the geometry, created crack, and the loading conditions of the prepared samples, the fracture occurs for the SCB samplesunder a less needed force. The results also indicate that the SCB testsamplesyield more fracture toughness
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    IN VITRO AND IN SILICO EVALUATION OF ANTICANCER ACTIVITY OF N,N-DIMETHYLAMINOMETHYLFERROCENE
    (university of eloued -جامعة الوادي, 2019-05-01) Adaika, A; Lanez, T; Lanez, E
    The aim of this study was to examine the interaction of DNA with the ligand N,N-dimethylaminomethylferrocene(NDF) in buffer phosphate solution(pH = 7.2) by electronic spectroscopy, electrochemical and molecular docking technics. The electrochemical results showed that the binding constant and free binding energy of the adduct DNA-NDF is equal to 1.48×10-4and -23,81 KJ.mol-1respectively. These results were in good agreement with those obtained from electronic spectroscopie assays;furthermore the interaction was also confirmed by the low value of diffusion coefficient of the bounded ligand1.83×10-8cm2.s-1as compared to the free ligand 2.13×10-8cm2.s-1. In addition the in silico study by molecular docking confirms the obtained in vitroresults. Molecular docking further indicated that the ligand is binds to DNA via a hydrogen bond betweenitsnitrogen atom and the oxygen number 4 of the deoxyadenine of the DNA B-chain
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    TRACE METAL CONCENTRATIONS IN SURFACE WATER AND PORE WATER SEDIMENT OF COASTAL AQUACULTURE PONDS, BANGLADESH
    (university of eloued -جامعة الوادي, 2019-05-01) Palash, Md. A; Islam, Md. S; Bayero, A. S; Sani, S; Koki, I.B
    Thisstudy investigates contamination of surface water and pore water sediment by trace metalsat the three coastal fish farms of Noakhali district in Bangladesh using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). The World Health Organization (WHO) and United States Environmental Protection Agency (USEPA)standards were used as the baseline for the evaluation of surface water pollution and contamination of the sediments respectively. Cr and Cd concentrations in the surface waterexceeded the reference limit, but there was no metal contamination of the pore water sediment.The average tracemetals concentrations in both surface waterand pore water sediment respectively showed similar trendsCr> Pb > Cu> Zn > Cd.All the metalsstudiedexhibitnegativeIgeovaluesand CF<1indicating uncontaminated sediment quality. The results of this study indicate that surface water of aquaculture ponds may be a possible source of trace metals which could be of health concern