ANTIBACTERIAL ACTIVITY OFGVL,A LECTIN ISOLATED FROM MARINE ALGAE GRACILARIA VERRUCOSA

Abstract

Lectins are univalent or polyvalent carbohydrate -binding proteins of non-immune origin that are widely distributed inthemarine ecosystem.A lectin was isolated from marine algaeGracilariaverrucosaby G-100 gel filtration chromatography. This lectin was named GVL, agglutinated rat, rabbit, goat, chicken and human ABO erythrocytes.The antibacterial activity of this algal lectin was studied using disc diffusion method. GVLexhibited potent antibacterial activity against bacteria such as E.coli,S.pyogenes,S.aureus,E.faecalis,B.subtilisandcoagulase-negative Staphylococci(CoNS)by disc-diffusion method.Also,the results were compared with standard antibiotic Ampicillin. These findings indicate that GVL is having therapeutic applications with great importance in clinical microbiology