SYNTHESIS, CHARACTERIZATION, ANTIBACTERIAL AND TOXICOLOGICAL STUDIES OF HETEROLEPTIC ACETYLSALICYLIC ACID AND ANTHRANILIC ACID METAL COMPLEXES
No Thumbnail Available
Date
2022-12-16
Journal Title
Journal ISSN
Volume Title
Publisher
university of el oued/جامعة الوادي
Abstract
This present study
aims at evauating the antibacterial, analgesic, and toxicologic al activities
of new metals [Ni(II), Cu(II), Cd(II), and Zn(II)] complexes deri v ed from acetylsalicylic acid
and anthranilic acid via refluxing method in a 1:1:1 stoichiometry ratio. Characterization was
executed using melting point, molar conductance, infrared and ultraviolet visible
spectroscopies . The antibacterial activities were investigated by the agar well diffusion
method. The toxicological effect of the test compounds in serum and kidney homogenates of
Wister rats was investigated. The screened complexes showed better antibacterial activitie s
than their free li gands. The resu l t of the analysis indicated that acetylsalicylic acid possessed a
good significant analgesic activity, while toxicological studies confirmed that the complexes
were toxic at the level of administered dosage.
Description
Article
Keywords
A ntibacterial, Toxicology, Analgesic s , Anthranilic acid, Acetylsalicylic acid
Citation
Merc y O. Bamigboye Bamigboye1, Ikechukw u P. Ejidike, Waha b A. Osunniran, Juliana B. Adetunji , Joshu a A. Obaleye Catherin e A. Adenipekun, SYNTHESIS, CHARACTERIZATION, ANTIBACTERIAL AND TOXICOLOGICAL STUDIES OF HETEROLEPTIC ACETYLSALICYLIC ACID AND ANTHRANILIC ACID METAL COMPLEXES.Journal of Fundamental and Applied Sciences.VOL15 N01.16/12/2022.university of el oued [visited in ../../….]. available from [copy the link here]