دراسة النشاط المضاد للأكسدة لمستخلصات نبات القرطوفة : Cotula cinerae

Abstract

Medicinal plants are famous for their ability to produce compounds of different chemical structures. These compounds have a major and vital role in the field of pharmacology. Accordingly, we carried out a study about the antioxidation activity for some extracts taken out of three distinct samples which are Cotula cinerae in order to enrich the list of the medicinal plants in Algeria and to valorize these effective compounds and the natural vegetal products; after the total quantitative estimation of phenolic compounds. After having them extracted and purified by following Folin-Ciocalteu method; we did the quantitative estimation of the phenolic compounds. We noticed that the percentage of phenolic compounds content ranged between 4..2 and 80.0. mgEAG/gMS. Compared to the yield of the other extracts the ethyl acetate extract gave a high return. In general, the content of the phenolic compounds is high in the ethyl acetate and dichloromethane extracts of both solvents (Acetone /H2O)and(MeOH/H2O). This is compared with the hexane extract. We aimed at studying the ability of antioxidation activity for these extracts. We carried out DPPH test in order to measure the extracts ability in inhibiting the free radical DPPH. The results has shown that EC50 values fluctuated between 802.1 and 130.98g/l These results indicate that the antioxidant efficacy of these extracts is weak when compared to the reference compounds, but they remain significant in large concentrations that exceed 100 g / l .