Study of socio-clinical risk factors and the pathophysiological variation of biological and oxidative stress markers of polycystic ovary syndrome in women

Abstract

Polycystic ovary syndrome is one of the most common hormonal disorders and represents one of the causes of women's inability to have children. Therefore, the aim of our work is an evaluation of some risk factors and some biological and oxidative stress markers among polycystic ovary syndrome (PCOS) Women in El-Oued region. Our risk factor study was conducted on a group of 76 women who were diagnosed by specialized doctors (38 healthy and 38 polycystic ovaries), with 11 women volunteering to provide blood, saliva and urine samples to study the biological markers (hematological, biochemistry, and oxidative stress markers) for the examination and follow-up of polycystic ovaries. About risk factors study, our results showed a strong correlation between polycystic ovaries and social, economic behaviors as well as diet, and on the other hand, genetic factors. But the high levels of Nervous, menstrual period and year of taking pills are the most dangerous factors (OR=3.11; OR=9.205; OR=5.940) respectively, Conversely playing sport and movement in daily life are considered the important protective factors against this disease. Our result demonstrated that a significant increase (P > 0.05) in blood glucose, total cholesterol and Triglycerides levels and a significant decrease (P > 0.01) in HDL level in women with PCOS patients as compared to controls. The results of the hematological analysis show a significant decrease in WBC (P < 0.000), MCV (P < 0.05) HGB, RBC, CMH but a significant increase (P < 0.05) in sedimentation rate in the PCOS patients group as compared to the control group. Our result showed also that a significant increase ( P < 0.05 ) of MDA level and SOD activity ( P < 0.05) in serum and saliva of patient group compared to control group. In conclusion, several social and nutritional factors, as well as disorders of the reproductive organs, contributed to the spread and development of polycystic ovaries in El-Oued region. In addition to a change in blood components, biochemical parameters and their relationship to oxidative stress, this contributes to disease development and the occurrence of complications.