Epidemiological and risk factor study, evaluation of biochemical and hematological parameters and Receiver Operating Characteristic Curves analysis of some oxidative stress markers in man and women stroke Patients of Touggourt region

Abstract

Stroke is one of the important cerebrovascular diseases and it represent leading cause of mortality and disability in the world . The aim of our work is carried out an epidemiological study, evaluation of some risk factors and biological and oxidative stress markers in patients with stroke in Touggourt region . Our epidemiological study was carried on 605 stroke patients admitted to hospital Sliman Amirat in the period (January 2014 to August 2018) in Touggourt region .Our socioeconomic risk factors study was conducted on 130 voluntary (65 healthy voluntary and 65 stroke patients), with 40 control and stroke persons were used for biological markers study (Hematological , Biochemical, Electrolyte, and oxidative stress markers ) for screening and follow-up stroke . The results of epidemiological study, show that 605 cases of stroke recorded 84% of patients were aged more than 50years. On the other hand, 47% of stroke patients are men versus 53% are women. In this study, 60% of the patients had a ischemic stroke whereas 15% of the people were affected by hemorrhagic stroke. Concerning length of stay,

the majority cases 80% stay in hospital less to 10 days of a total cases study. Concerning the risk factors study , our results demonstrated that a strong association between some socioeconomic behaviors and clinical history with stroke . But the high levels of family stress and excess in treatment with anticoagulants are the most dangerous risk factors with ( OR = 12,687 , OR=12,310 ) respectively , in contrast the brush of teeth daily and anemia safety are important protective factors against this disease . For the biological study , our results revealed significant change ( p< 0,05 ) of some hematological , biochemical , electrolytes and oxidative stress markers in stroke patients as compared to controls with a simple differences between women and men . From this study we found that some of oxidative stress markers have a high sensitivity , specificity and AUC values which qualify them to be important marker for diagnosing and predicting stroke in women and men . On one hand this study showed a significant (p<0,05) relationship between the changes of some specifics oxidative stress markers with one of the hematological , electrolyte or biochemical markers . on the other hand we found a significant relationship (p<0,05 ) between some oxidative stress markers and risk factors . In conclusion several socioeconomic and clinical factors contributed to the dispersion and development of the stroke in Touggourt region . in addition A change in hematological , biochemical , electrolyte markers and their relationship with oxidative stress contributes to the development or complication of the disease after stroke. Suggesting that MDA and SOD testing used as systemic marker for screening and followed stroke treatment .