Investigation of the Oxidative Stress markers in salivary, serum and erythrocyte ofEl-Oued (Algeria) Diabetic Patients

Abstract

The aim of this study was to evaluate the state of oxidative stress during diabetes in El-Oued (Algeria) patients. The experimentation is carried out on 72 voluntary individuals were divided into three groups. The first group of healthy individuals (controls), the second group diabetic type 1and the third group diabetic type 2, on which we measured some biochemical parameters on serum, erythrocytes and saliva. The Results showed a significant decrease in serum uric acid concentration in diabetics type 1 (10.78%) and diabetics type 2 (26.83%) and a significant decrease (p <0.05)in erythrocytes GSH in both types of diabetes compared to controls. On the other hand, there was a significant increase (p <0.05) in serum and salivary peroxidation lipidique (MDA) in type 1 and 2 diabetics compared to non-diabetics. In addition, a significant correlation (p <0.05) between serum and salivary MDA in type 1 diabetics (R2 = 0.750) and type 2 diabetics (R2 = 0.768) was shown in this study. In conclusion the present study reveals that diabetes induces an imbalance of oxidant / antioxidant status at serum, erythrocyte and salivary level and that salivary MDA is a good indicator of the state of oxidative stress in diabetes.