(university of eloued جامعة الوادي, 2024-01-12) Maroua Fattouche1, Salah Belaidi1*, Touhami Lanez2
This study is fundamental research on the structure- activity relationships in 16-membred
macrolides. It is based on the molecular modelling (molecular mechanics, molecular
dynamics, distribution de Boltzmann, PM3, SAR,). We defined the structural motives
intervening in antibiotic macrolide properties. The compounds substituted in positions (C2,
C4, C8, and C15) are the most stables and the less stable is substituted in C12. The
rokitamycine which has the most elevated value of partition coefficient: 3.06. This antibiotic
is lipophilic, so it has good permeability across the biological membrane, better fixation on
plasma proteins and elimination by metabolic route.
