Browsing by Author "Darshan Raj, C. G."

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Antibacterial And In Vitro Antioxidant Activities Of Some 4-amino-1,2,4-triazole-5(4h)-thione Derivatives
(University of Eloued جامعة الوادي, 2015-09-01) Manjula, P. S.; Sarojini, B. K.; Darshan Raj, C. G.
This work represents the synthesis and characterization some new versatile intermediates namely 4-amino-1,2,4-triazole-5(4H)-thione derivatives in a one-step fusion method. The method works to be superior compared to the existing method by Reed and Handel which consists of four steps. The antibacterial activity of compounds is tested against Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, Staphilococcus aureus. The compounds exhibited species specific activity. Among the tested compounds, 1a and 1b exhibited good activity at moderately low concentration (31.25µg/mL) against tested strains of bacteria. DPPH (1,1-diphenyl-2-picryl-hydrazyl), FRAP (ferric reducing antioxidant power) and Lipid peroxidation assays are performed to determine the in vitro antioxidant activities. The compound 1e exhibited good antioxidant activity among the tested compounds.
Antistress And Antimicrobial Studies Of Biphenyl Chalcone Derivatives
(University of Eloued جامعة الوادي, 2016-09-01) Darshan Raj, C. G.; Sarojini, B. K.; Sindhu Priya, E. S.; Hassan Khan, M. T.; Srinivas, C.; Manjula, P.s .
This work reports the synthesis, characterization of new (2E)-1-(biphenyl-4-yl)-3-aryl)-prop-2-en-1-one derivatives (C1-C10). The chalcone derivatives were evaluated for in vitro antibacterial, antifungal, antioxidant activities. The compounds exhibited moderate to good antimicrobial activity at MIC 10-40 µg/mL. The compounds were docked at the active site of the methionyl-tRNA synthetase (metRS) (PDB ID: 1A8H) to predict their putative interactions. The compounds further screened for antioxidant property, amid C5, C7 and C8 exhibited good DPPH radical scavenging activity. Compound C5 was selected for antistress studies against gamma radiation induced oxidative stress markers in E .coli K 12. The C5 pretreatment and irradiated bacteria sample showed modulatory action of stress enzymes SOD and CAT to near basal level and significant demulating effect on the level of TBARS.
An Exploration On The Synthesis And Bio-applications Of Derivatives Of Heterocyclic Mannich Bases
(University of Eloued جامعة الوادي, 2016-01-01) Manjula, P.s.; Sarojini, B. K.; Narayana, B.; Darshan Raj, C. G.
The Mannich reaction is a three-component reaction of an aldehyde, a primary or secondary amine and a ketone which is one of the most powerful C-C bond forming reactions in organic synthesis. It leads to β-amino carbonyl compounds, which are useful for the syntheses of nitrogen containing compounds, such as natural products and medicinally relevant compounds. The versatility and potential of these compounds to introduce both functional and structural diversity using the Mannich reaction have stimulated the creativity of chemists. Keeping in view of the importance of this organic moiety in the field of medicine and biology here an attempt has been made to review the synthesis and biological importance of heterocyclic Mannich base derivatives.