An Exploration On The Synthesis And Bio-applications Of Derivatives Of Heterocyclic Mannich Bases
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Date
2016-01-01
Journal Title
Journal ISSN
Volume Title
Publisher
University of Eloued جامعة الوادي
Abstract
The Mannich reaction is a three-component reaction of an aldehyde, a primary or secondary amine and a ketone which is one of the most powerful C-C bond forming reactions in organic synthesis. It leads to β-amino carbonyl compounds, which are useful for the syntheses of nitrogen containing compounds, such as natural products and medicinally relevant compounds. The versatility and potential of these compounds to introduce both functional and structural diversity using the Mannich reaction have stimulated the creativity of chemists. Keeping in view of the importance of this organic moiety in the field of medicine and biology here an attempt has been made to review the synthesis and biological importance of heterocyclic Mannich base derivatives.
Description
Articale in Journal of fundamental and Applied Sciences Vol. 08, N. 01
Keywords
Amines, β-amino carbonyl compounds, Biological activity, Heterocyclic Mannich base derivative, Ketones, Mannich reaction.
Citation
Articale in Journal of fundamental and Applied Sciences Vol. 08, N. 01