IJBAR_Vol 01 N 02

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Browsing IJBAR_Vol 01 N 02 by Author "Bouazza, Marwa"

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    Evaluation of the effect of spinosad on lipid peroxidation and antioxidant markers in female mice
    (University of Eloued جامعة الوادي, 2018-12-01) Saadi, Leila1; Bouazza, Marwa; Mokrane, Ahlam; Aicha, Meriem; Lebaili, Nemcha
    A Like any synthetic substance, or even natural, pesticides can produce harmful effects on human and animal health. The purpose of the present study is to evaluate the oxidative profile following the exposure of female mice to 9.2 mg/kg/day of spinosad. This is to examine the relationship between insecticide exposure and the risk of developing oxidative stress. Adult mice of the Naval Medical Research Institute were given by gavage daily for 18 days with spinosad, at rate of 9.2 mg/kg/day. Short-term exposure caused lipid auto-oxidation, expressed as an increase in malondialdehyde concentration in treated mice. Lipid peroxidation is associated with high level of plasma total anti-oxidative power and low level of plasma vitamin C. These results support the toxicity of the bioinsecticide witch induce oxidative stress in female mice
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    Investigation of renal toxicity induced by neonicotinoid (thiamethoxam) insecticide in mice
    (University of Eloued جامعة الوادي, 2018-12-01) Saadi, Leila; Raki, Ahmed Aziz; Bouazza, Marwa
    The investigation of the toxicity of a neonicotinoid insecticide, thiamethoxam, in mammals has been the subject of several experimental studies. In the present work, we are particularly interested in studying the renal toxic effects of two doses (0.2 and 0.4 mg/kg/day) of thiamethoxam, an insecticide widely marketed in Algeria, administered orally in adult male mice. For this purpose, a renal histopathological study and plasma assays of the uremia and the creatinemia are carried out. Examination of the histological sections recorded dose-dependent lesions in the renal parenchyma. Renal impairment is characterized by the destruction of certain glomeruli and the presence of some hemorrhagic and inflammatory foci. These alterations are associated with leukocyte diapedesis presented in the blood vessels. The renal function is maintained in the normal state because the urea and creatinine contents remain unchanged. On the basis of these results, it turns out that thiamethoxam treatment induces a dose-dependent renal toxicity in male mice.