International Journal of Biological and Agricultural Research

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Browsing International Journal of Biological and Agricultural Research by Author "DEROUICHE, Samir"

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    Ameliorative effect of Aristolochia longa and Aquilariamalaccensison lead acetate inducednephrotoxicityin female rats
    (University of Eloued جامعة الوادي) DEROUICHE, Samir; GHARBI, Safa; ZEGHIB, Khaoula; KHELEF, Yahia
    Background:Aquilariamalaccensis And Aristolochia longa are plants used extensively in traditional medicine for the treatment of cancer in several regions in Algeria. We investigate the ameliorative effect of Aristolochia longa and Aquilariamalaccensison kidney toxicity induced by lead in female albino rats. Methods:Twenty five (25) apparently healthy female Wistar rats were randomly divided into five groups of five rats in each: control, Pb, Pb + A. longa (Ar), Pb+ A. malaccensis (Aq), and Pb+Ar+Aq. lead (100 mg/kg b.w) as Pb(C2H3O2)2 added in their drinking water for 75 days. A. longa (rhizome powder at a dose 1% w/w of diet) and A. malaccensis (heartwood powder at a dose 1% w/w of diet) were added to the feed during the last 15 days of lead exposed in the animals. Results:Obtained results revealed that lead treatment caused a significant increase in blood glucose level, serum urea, creatinine and uric acidlevel and in kidneyof MDA level and CAT activity. In contrast, it led to an decrease in the kidneyGST activityand GSH level in rats .Also, the results clearly showed that lead causes alterations of glomerular and tubular structure in comparison with controls.Our results showed that treatment with A. malaccensis and A. longa a partial correction of the previous parameters.The histological observations confirmed the nephroprotection results by the biochemical parameters. Conclusion:Results demonstrated beneficial effects of A. longa and A. malaccensis treatment againacetate lead-induced toxicity and kidney damage in rats
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    Investigation of the Oxidative Stress markers in salivary, serum and erythrocyte ofEl-Oued (Algeria) Diabetic Patients
    (University of Eloued جامعة الوادي, 2018-06-01) DEROUICHE, Samir; HABITA, Asma; DEGACHI, Ouidad; NECIB, Maroua; CHETEHOUNA, Roumaissa
    The aim of this study was to evaluate the state of oxidative stress during diabetes in El-Oued (Algeria) patients. The experimentation is carried out on 72 voluntary individuals were divided into three groups. The first group of healthy individuals (controls), the second group diabetic type 1and the third group diabetic type 2, on which we measured some biochemical parameters on serum, erythrocytes and saliva. The Results showed a significant decrease in serum uric acid concentration in diabetics type 1 (10.78%) and diabetics type 2 (26.83%) and a significant decrease (p <0.05)in erythrocytes GSH in both types of diabetes compared to controls. On the other hand, there was a significant increase (p <0.05) in serum and salivary peroxidation lipidique (MDA) in type 1 and 2 diabetics compared to non-diabetics. In addition, a significant correlation (p <0.05) between serum and salivary MDA in type 1 diabetics (R2 = 0.750) and type 2 diabetics (R2 = 0.768) was shown in this study. In conclusion the present study reveals that diabetes induces an imbalance of oxidant / antioxidant status at serum, erythrocyte and salivary level and that salivary MDA is a good indicator of the state of oxidative stress in diabetes.