Investigation of the Oxidative Stress markers in salivary, serum and erythrocyte ofEl-Oued (Algeria) Diabetic Patients
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Date
2018-06-01
Journal Title
Journal ISSN
Volume Title
Publisher
University of Eloued جامعة الوادي
Abstract
The aim of this study was to evaluate the state of oxidative stress during diabetes in El-Oued (Algeria)
patients. The experimentation is carried out on 72 voluntary individuals were divided into three groups. The
first group of healthy individuals (controls), the second group diabetic type 1and the third group diabetic type
2, on which we measured some biochemical parameters on serum, erythrocytes and saliva. The Results
showed a significant decrease in serum uric acid concentration in diabetics type 1 (10.78%) and diabetics
type 2 (26.83%) and a significant decrease (p <0.05)in erythrocytes GSH in both types of diabetes compared
to controls. On the other hand, there was a significant increase (p <0.05) in serum and salivary peroxidation
lipidique (MDA) in type 1 and 2 diabetics compared to non-diabetics. In addition, a significant correlation (p
<0.05) between serum and salivary MDA in type 1 diabetics (R2
= 0.750) and type 2 diabetics (R2
= 0.768)
was shown in this study. In conclusion the present study reveals that diabetes induces an imbalance of
oxidant / antioxidant status at serum, erythrocyte and salivary level and that salivary MDA is a good
indicator of the state of oxidative stress in diabetes.
Description
Articale in International Journal of biological and Agricultural Research Vol. 01 N. 01
Keywords
Diabetes, Oxidative stress, Uric acid, GSH, saliva MDA
Citation
Articale in International Journal of biological and Agricultural Research Vol. 01 N. 01