Zinc Supplementation Overcomes Effects of Copper on Zinc Status, Carbohydrate Metabolism and Some Enzyme Activities in Diabetic and Nondiabetic Rats

dc.contributor.authorDEROUICHE, Samir
dc.contributor.authorKechrid, Zine
dc.date.accessioned2023-07-04T13:22:28Z
dc.date.available2023-07-04T13:22:28Z
dc.date.issued2016-08-01
dc.descriptionArticleen_US
dc.description.abstractObjective: The aim of this study was to investigate the effect of zinc supplementation on zinc status, carbohydrate metabolism and some enzyme activities in rats with alloxan-induced diabetes that were fed high-copper feed. Methods: Male albino Wistar rats were randomly divided into 6 groups (n=10). The first and fourth groups were nondiabetic and diabetic controls. The second, third, fifth and sixth groups were copper, copper + zinc, diabetes + copper and diabetes + copper + zinc groups, respectively. Diabetes in the fourth, fifth and sixth groups was induced by alloxan. Copper (30 mg/kg feed) as CuSO4 5H2O and zinc (231 mg/kg feed) as ZnSO4 7H2O were added to the feed of the animals in the copper and zinc groups for 21 days. Results: Copper supplementation caused a significant decrease in body weight gain, serum zinc, tissue zinc, serum protein concentrations, alkaline phosphatase, lactic dehydrogenase and amylase activities. In contrast, it led to an augmentation in creatinine, uric acid and transaminases activities in rats with and without diabetes. Zinc supplementation in the feed for animals given copper ensured a partial correction of the previous parameters. Conclusions: The study demonstrated the beneficial effects of zinc treatment in copper-induced metabolic disturbance in diabetic and nondiabetic ratsen_US
dc.identifier.citationSamir Derouiche, Zine Kechrid, Zinc Supplementation Overcomes Effects of Copper on Zinc Status, Carbohydrate Metabolism and Some Enzyme Activities in Diabetic and Nondiabetic Rats, Canadian Journal of Diabetes, Volume 40, Issue 4, 2016en_US
dc.identifier.issn1499-2671
dc.identifier.urihttps://dspace.univ-eloued.dz/handle/123456789/27532
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectalkaline phosphatase, copper, diabetes, transaminases, zincen_US
dc.titleZinc Supplementation Overcomes Effects of Copper on Zinc Status, Carbohydrate Metabolism and Some Enzyme Activities in Diabetic and Nondiabetic Ratsen_US
dc.typeArticleen_US

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