EXAMINING THE EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF MOMORDICA CHARANTIA FRUIT ON AVOIDANCE MEMORY ALTERATIONS IN MICE USING STEP-THROUGH MODEL
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Date
2019-01-01
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university of el oued/جامعة الوادي
Abstract
Medicinal plants have been, and still are, of a particular value and importance for public
health provision in terms of both treatment and prevention of diseases. Among the effects of
such plants are the impacts on the memory and learning process. In this study, the effect of
hydroalcoholic extract of Momordica charantia on the avoidance memory alterations was
investigated in mice using the step-through model. The hydroalcoholic extract of the soaked
plant was administered to the mice at doses of 10, 25, 50, 100, and 200 mg/kg by gavage
(intragastric tube) method. In comparison with the control group receiving only drinking
water, the highest memory improvement was observed at a dose of 25 mg/kg. The results of
interferential intraperitoneal administration of scopolamine and the extract gavage at a dose of
25 mg/kg indicated the ability to restore scopolamine-induced memory corruption by the total
extract of M. charantia.
Description
Article
Keywords
Momordica charantia, scopolamine, avoidance memory, step-through, mice.
Citation
A. Miri, S. F. Askari, E. Shahraki,EXAMINING THE EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF MOMORDICA CHARANTIA FRUIT ON AVOIDANCE MEMORY ALTERATIONS IN MICE USING STEP-THROUGH MODEL .Journal of Fundamental and Applied Sciences.VOL11 N01.01/01/2019.university of el oued [visited in ../../….]. available from [copy the link here]