Toxicological assessment of the aqueous leaves extract of Combretum platypterum (Welw) Hutch & Dalziel
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Date
2022-12-30
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جامعة الوادي - University of Eloued
Abstract
Combretum platypterum belongs to the family of Combretaceae. The leaf is used to treat fever,
conjunctivitis, febrifuge, coughs, sexually transmitted diseases, diarrhea, and as a tonic.
Despite it being used in ethnomedicine to treat various sicknesses, the safety profile of the leaf
extract has not been reported. This study was aimed at testing the acute and sub-acute
toxicological assessments of the aqueous leaf extract of Combretum platypterum.The acute
study was carried out using mice and rats. In sub-acute experiments, the animals received 0.5,
1, and 2.5 g/kg of the plant extract orally per day for 28 days. The first weight and the last
weight were taken. The liver, spleen, kidney, heart, lungs, and stomach were obtained,
weighed, and fixed. Blood was obtained for haematology and biochemical assays. The LD50
of the root extract was indeterminable since there was no death in the mice and rats used. The
leaf extract significantly increases (p<0.05) the body weight at the dose of 2.5g/kg compared
to control. The body weight index was not affected compared to control (p>0.05). At 0.5 and 1
g/kg, the extract significantly increased the level of monocytes (p < 0.05) compared to the
control. haematological parameters were not affected. Upon bichemical analysis of the leaf
extract, 2.5 g/kg significantly (P<0.05) increased the level of HDL and 0.5 and 1 g/kg
significantly (P<0.05) increased the level of TRI compared to control. Other parameters were
not affected. This study shows that aqueous root extract is safe.
Description
article
Keywords
Combretum platypterum, Leaf, Toxicological, Herbal medicine, Safety.
Citation
.DICKSON, UWAYA UWAYA , MacDonald, Idu . Toxicological assessment of the aqueous leaves extract of Combretum platypterum (Welw) Hutch & Dalziel . Algerian Journal of Biosciences . Vol 03. N 02. 30/12/2022. University of Eloued .[Write down the date][Copy the download link ]