Browsing by Author "Salah Eddine Laouini"

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    Enhanced of Photocatalytic Activity of Biosynthesized ZnO/CuO/Cu2MgO3 Nanoparticles for the Degradation of Bromocresol Green
    (University of Eloued, 2023-12-11) Tabet Amina; Souhaila Meneceur; Salah Eddine Laouini; Salmi Chaima; Hamdi Ali Mohammed; Iman Kir
    The current investigation is centered on the sustainable synthesis, physical characterization, and performance evaluation of various metal oxide nanoparticles (NPs) produced utilizing an extract derived from Common Rue. Following the synthesis of metal oxide NPs, including ZnO/CuO/Cu2MgO3, a comprehensive characterization was carried out employing various techniques such as FTIR, UV, XRD, and SEM to scrutinize their chemical and physical attributes. Photocatalytic activity was evaluated by assessing their effectiveness in degrading bromocresol green, an anionic dye. The characterization results substantiated the successful fabrication of ZnO/CuO/Cu2MgO3 nanoparticles. X-ray diffraction analysis verified the presence of hexagonal ZnO and monoclinic CuO nanoparticles within the nanocomposite, along with cubic Cu2MgO3. Scanning electron microscopy illustrated well-defined, spherical nanocomposite particles with an average size of approximately 70 nm. Fourier transform infrared spectroscopy demonstrated the coexistence of both organic and inorganic components within the nanocomposite. These nanoparticles exhibited respective band gap energies of 1.5 eV. The study on photocatalytic activity revealed a substantial removal of the organic dye by the synthesized nanoparticles, achieving a degradation coefficient of 99.66% at 75 minutes. These findings underscore the efficacy of ZnO, MgO, and CuO nanoparticles, suggesting their potential as a cost-effective and environmentally safe alternative for water treatmen
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    Molecular docking studies of silver nanoparticles (AgNPs) for their potential use against SARS-CoV-2
    (University of Eloued, 2023-12-11) Henda Daoudi; Abderrhmane Bouafia; Salah Eddine Laouini; Mamoun Fellah; Selmi Boulbaba
    Comprehending the COVID-19 pandemic and preventing future coronavirus pandemics hinges on our ability to grasp the evolutionary strategies employed by the SARS-CoV-2 Omicron variant. In the present investigation, we determined the crystal structure of the receptor-binding domain (RBD) from currently circulating omicron subvariant XBB.1.5 complexed with silver nanoparticles AgNPs. The primary function of the spike protein RBD is to bind to the receptor angiotensin-converting enzyme 2 human cellular receptor (hACE2) that helps the virus enter the host cell . The docking studies revealed that AgNPs have the capacity to bind to the spike protein RBD, potentially elucidating their antiviral effects against SARS-CoV-2 . Obtained results showed a favorable binding energy of -10.2 Kcal/mol between the nanoparticles and the protein target. According to the docking analysis, AgNPs formed four bonds at the binding site, three hydrogen bond between ALA153 of spike protein and Ag atom, and one σ bonds between LEU281 of spike protein and Ag atom, underscoring their interaction with the active site. AgNPs exhibit potential as effective agents against viruses raising the possibility of their use in the treatment and prevention of COVID- 19 and used to develop effective antiviral drugs
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    Molecular docking studies of silver nanoparticles (AgNPs) for their potential use against SARS-CoV-2
    (University of Eloued, 2023-12-11) Henda Daoudi; Abderrhmane Bouafia; Salah Eddine Laouini; Mamoun Fellah; Selmi Boulbaba
    Comprehending the COVID-19 pandemic and preventing future coronavirus pandemics hinges on our ability to grasp the evolutionary strategies employed by the SARS-CoV-2 Omicron variant. In the present investigation, we determined the crystal structure of the receptor-binding domain (RBD) from currently circulating omicron subvariant XBB.1.5 complexed with silver nanoparticles AgNPs. The primary function of the spike protein RBD is to bind to the receptor angiotensin-converting enzyme 2 human cellular receptor (hACE2) that helps the virus enter the host cell . The docking studies revealed that AgNPs have the capacity to bind to the spike protein RBD, potentially elucidating their antiviral effects against SARS-CoV-2 . Obtained results showed a favorable binding energy of -10.2 Kcal/mol between the nanoparticles and the protein target. According to the docking analysis, AgNPs formed four bonds at the binding site, three hydrogen bond between ALA153 of spike protein and Ag atom, and one σ bonds between LEU281 of spike protein and Ag atom, underscoring their interaction with the active site. AgNPs exhibit potential as effective agents against viruses raising the possibility of their use in the treatment and prevention of COVID- 19 and used to develop effective antiviral drugs