Browsing by Author "Rechreche, H."

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    Contribution To Study The Glycoprotein Ligands Of The Cerebellar Soluble Lectin In Human K562 Tumour Cells
    (University of Eloued جامعة الوادي, 2016-09-01) Rechreche, H.; Zanetta, J.p.
    Many cancer cells over-express significantly the glycoproteins specific to the endogenous cerebellar soluble lectin or CSL. These ligands may present the same electrophoretic profiles regardless of the specie or tissue. We purified a large amount of the active CSL using an immuno-affinity chromatography, which was used to isolate the CSL ligands from human tumour K562 cell lines. After protease digestion of these ligands, we analyzed the obtained peptides using reverse phase chromatography and isolated an overrepresented group that carried N-glycans and was relatively hydrophobic. Thus, we suggested that the CSL ligands have a common pepetide sequence specifically recognized by the CSL, who could direct the production of these CSL-recognized N-glycans. Moreover, we speculated that the expression deregulation of a specific exon encoding this peptide sequence alters the glycosylation in K562 tumour cells.
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    RETROSPECTIVE STUDY OF EPIDEMIOLOGICAL, CLINICOPATHOLOGICAL AND BIOLOGICAL PROFILS OF 62 COLORECTAL CANCERS (CRC) CASES IN JIJEL PROVENCE (ALGERIA)
    (University of Eloued جامعة الوادي, 2018-01-01) Abbes, A.; Rechreche, H.; Brinet, R.; Boulkhiout, S.; Souilah, N.; Benali, M.
    In Algeria, the CRC wing and become the first digestive cancer in both sexes, outperforming stomach cancer. To enrich the Algerian cancer registries, we analyzed the profiles of patients with these cancers in Jijel Willaya. This was a retrospective and descriptive analysis of epidemiological, clinicopathological and biological profiles of 62 CRC cases. We found that the CRC represented the first type of digestive cancers in which the three quarters were colon cancers. The most affected age group was 60-70 years with a male predominance and an average age of 56.20 years. The bleeding and abdominal pain were the majority telltale signs. The combined chemotherapy has been standardized with all patients and the Lieberkühnien adenocarcinoma was the major histological form. The the disease issue and the choice of therapy depended on the K-RAS gene mutations. Our results were often compatible with the available literature and may provide reliable and relevant data on this disease.