Repository logo
Communities & Collections
All of DSpace
  • English
  • العربية
  • বাংলা
  • Català
  • Čeština
  • Deutsch
  • Ελληνικά
  • Español
  • Suomi
  • Français
  • Gàidhlig
  • हिंदी
  • Magyar
  • Italiano
  • Қазақ
  • Latviešu
  • Nederlands
  • Polski
  • Português
  • Português do Brasil
  • Srpski (lat)
  • Српски
  • Svenska
  • Türkçe
  • Yкраї́нська
  • Tiếng Việt
Log In
New user? Click here to register. Have you forgotten your password?
  1. Home
  2. Browse by Author

Browsing by Author "Maroua Fattouche1, Salah Belaidi1*, Touhami Lanez2"

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • Results Per Page
  • Sort Options
  • Loading...
    Thumbnail Image
    Item
    STRUCTURAL INVESTIGATIONS AND STRUCTURE-ACTIVITY RELATIONSHIPS IN A SERIE OF NEW ANTIBIOTIC 16- MEMBERED MACROLIDES
    (university of eloued جامعة الوادي, 2024-01-12) Maroua Fattouche1, Salah Belaidi1*, Touhami Lanez2
    This study is fundamental research on the structure- activity relationships in 16-membred macrolides. It is based on the molecular modelling (molecular mechanics, molecular dynamics, distribution de Boltzmann, PM3, SAR,). We defined the structural motives intervening in antibiotic macrolide properties. The compounds substituted in positions (C2, C4, C8, and C15) are the most stables and the less stable is substituted in C12. The rokitamycine which has the most elevated value of partition coefficient: 3.06. This antibiotic is lipophilic, so it has good permeability across the biological membrane, better fixation on plasma proteins and elimination by metabolic route.

DSpace software copyright © 2002-2025 LYRASIS

  • Privacy policy
  • End User Agreement
  • Send Feedback