Browsing by Author "Derouiche, Samir"

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Beneficial Effects of Aristolochialonga and Aquilariamalaccensis on Lead-Induced liver, kidney and Hematological Alterations in Rats
(University of Eloued جامعة الوادي, 2019-03-06) Derouiche, Samir; Zeghib, Khaoula; Gharbi, Safa; Khelef, Yahia
Biological properties and Acute Toxicity Study of Copper oxide nanoparticles prepared by aqueous leaves extract of Portulaca oleracea
(A & V Publications, 2020-06-03) Atoussi, Ouidad; Chetehouna, Sara; Derouiche, Samir
The aim of this study is to use the purslan (Portulacae oleracea L) leaves aqueous extract in order to prepare copper nanoparticles and to explore antioxidant and anti-inflammatory activity of aqueous extract of P.oleracea L and CuNPs. The nanoparticles were characterized from structural and morphological point of view by using analytical techniques such as: UV-Vis spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), and Scanning Electron Microscopy (SEM). Antioxidant activity of purslane and CuNPs was studied done FRAP assay also the anti-inflammatory and hemolysis essay were studies. The acute toxicity test was applied in Wistar albino rats. Obtain results show that the SEM analysis revealed that the particle size was found to be ranging under 46 nm. On the other hand, the copper nanoparticles and purslan possessed the reducing capacity when IC50 value was 68, 316 μg/ml and 79, 675 μg/ml respectively, the anti-inflammatory ability while IC50 value was 77, 503 μg/ml and 60, 727 μg/ml respectively. In this study, the toxicity test showed no mortality or behavioral change up to 20 mg/kg of albino Wistar rats CuNPs. We concluded that Portulaca oleracea L has potential properties as biocatalyst or natural stabilizers for CuNPs synthesis. Each CuNPs as P.oleracea L leaves extract were have a reducing and anti-inflammatory capacity which can be protect the cells against the degenerative effects of Reactive Oxygen Species (ROS).
Boulaares, ISlam. Characterization And Acute Toxicity Evaluation Of The Mgo Nanoparticles Synthesized From Aqueous Leaf Extract Of Ocimum Basilicum L
(جامعة الوادي - University of Eloued, 2020-08-31) Derouiche, Samir; Guemari, Imane Yousra; Boulaares, ISlam
The aim of this study was to prepare magnesium oxide nanoparticles (MgONPs) using aqueous leave extract of Ocimum basilicum L. and to evaluate their acute toxicity. The characteristics of biosynthesized MgO powder was analyzed by UV–Vis spectroscopy, scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The acute toxicity test of MgONPs was applied in Wistar albino rats with different concentration. Results showed that the broad bell-shaped spectrum band was obtained by UV–Vis spectroscopy indicates the formation of MgO. The SEM images provided further insight into the shape and size of MgO which to be ranging under 440 nm. Fourier transform infrared (FTIR) spectroscopy detected the vibration of the Mg─O bond that indicate the presence of magnesium oxide nanoparticles (MgO). In this study, the toxicity test showed no mortality or behavioral change in low dose of MgNPs (250 mg / kg b.w) but we observed that 50% of rats have died when treated with high dose of MgNPs (500 mg/kg b.w.). This study confirmed that aqueous extract of Ocimum basilicum L. has potential properties as biocatalyst for the biosynthesis of MgONPs without any toxicity under dose 250 mg/kg in rats.
Current Review on Herbal Pharmaceutical improve immune responses against COVID-19 infection
(A&V Publications, 2020-07-01) Derouiche, Samir
Coronavirus SARS-COV2 (COVID-19) represents the causative agent of a potentially fatal disease that is of great global public health concern. The pandemic outbreak of COVID-19 is rapidly spreading all over the world. This review aims to provide the role of Herbal Pharmaceutical in reducing the spread or complications of COVID-19 infection in the body of people. The evidence of generation of oxygen free radicals and oxidative stress is a key process in the onset of chronic disease which participate in the development of the systemic inflammatory response syndrome. Medicines of plant origin aroused a lot of interest due to their wide use, abundance, high efficacy and lack of secondary effects as an antioxidants and anti-inflammatory agents, antiviral efficacy or in their preventive efficacy of the immune system From it we suggest that the combination of conventional therapy and herbal medicine for patients infected with COVID-19 to reduce the complexities and development of the virus
Oxidative Stress Associated with SARS-Cov-2 (COVID-19) Increases the Severity of the Lung Disease - A Systematic Review
(Journal of Infectious Diseases and Epidemiology, 2020-05-04) Derouiche, Samir
COVID-19 patients have a higher risk of developing inflammatory responses associated with serious and even fatal respiratory diseases. This review focuses on the relationship between oxidative stress and COVID-19. Coronaviruses are a family of common RNA viruses that can cause serious lower respiratory tract infections, followed by bronchitis and pneumonia. Pulmonary inflammation, fever and fibrosis are symptoms of COVID-19 mediated by cytokine pro-inflammatory. Oxidative stress affect repair mechanisms and the immune control system, which is one of the main events of the inflammatory response which allows us also to conclude that oxidative stress is a major factor increasing the severity of COVID-19 especially during chronic diseases associated with the fragility of the antioxidant system, suggesting to recommend antioxidants supplementation in therapeutic strategies against COVID-19.
STUDY OF FLUORIDE-INDUCED HAEMATOLOGICAL ALTERATIONS AND LIVER OXIDATIVE STRESS IN RATS
(WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 2017-05) Djouadi, Anfal; Derouiche, Samir
Fluorine is a necessary biological trace element for human health. However, fluoride accumulation leads to cascading effects resulting in altered physiological functions in human being. The current studies evaluated the effect of fluoride induced hematological alterations and oxidative stress in the liver of experimental rats. For this purpose, adult female Wistar albino rats divided into control and NaF treated group. sodium Fluoride (400 mg/kg b.w) added in their drinking water for 70 days. Compared with the control, a significant decrease in the body weight gain (p<0.001) and increase in relative liver weight (p<0.001) were noticed in the NaF group Our results showed that fluoride treatment caused a increase in Granulocyte (p < 0.001), White blood cell (p < 0.001), Lymphocyte (p < 0.01) and Platelets (p < 0.01) compared with the control. In addition, it led to an increases in triglyceride (p<0.001), cholesterol (p<0.01) level, GOT (p<0.01) and GPT (p<0.001) activities in serum animal compared to the control group . In contrast fluoride caused an oxidative stress by decrease in GSH level and GST activity and increase in MDA concentration compared with the control group. In Conclusion, Results demonstrated the toxic effect of high-dose of fluoride by causing oxidative stress and inflammation in hepatic tissue.
Study of oxidative stress during pregnancy
(Juniper Publishers, 2017-10-10) Derouiche, Samir; Doudi, Dalal; Atia, Noura
Oxidative stress is defined as an imbalance in the balance between antioxidants and pro-oxidants in favor of antioxidants. The increase in lipid peroxidation and the significant decrease in GSH and total antioxidant power ORAC in the serum and erythrocytes of pregnant women especially during the third trimester of pregnancy clearly show the evolution of the state of stress oxidative therapy associated with pregnancy in pregnant women. So pregnancy is a physiological state characterized by oxidative disturbance that contributes to the initiation and progression of complications associated with pregnancy