ZEGHEB NadjibaBOUBEKRI CherifaLANEZ Touhami2024-06-132024-06-132019-02-24ZEGHEB Nadjiba.BOUBEKRI Cherifa.LANEZ Touhami .Evaluation of the anti-Alzheimer's disease activity of N-ferrocenylmethyl-2-nitroaniline using bioinformatics tools.International Symposium on Technology & Sustainable Industry Development, ISTSID’2019. Faculty Of Technology. University Of Eloued. [Visited in ../../….]. Available from [copy the link here].https://dspace.univ-eloued.dz/handle/123456789/33474InterventionInhibition of acetylcholinesterase is currently regarded as the leading strategy against Alzheimer's disease. The principal objective of this project was to investigate the acetylcholinesterase inhibitory activity of N-ferrocenylmethyl-2- nitroaniline (2FMNA) using the bioinformatics tools to predict the relationship between them. In this research, we based on docking study of the interaction between N-ferrocenylmethyl-2-nitroaniline and the AChE by using the open source software AutoDock tools. The X- ray crystal structure of the enzyme AChE (PDB ID :5HF5) were obtained from Protein Data Bank (http://www.rcsb.org./pdb). The N-ferrocenylmethyl-2-nitroaniline structure chosen for docking was optimized with the Gaussian 09 software by the DFT method and the set of B3LYP / 6-311G ++ (d, p) bases. The interaction parameters obtained from molecular docking show that the interaction between 2FMNA and the enzyme is of the electrostatic type.enN-ferrocenylmethyl-2-nitroanilinemolecular dockingenzyme acetylcholinesterase (AChE)Alzheimer's disease.Intervention