R., . Boukli-Hacene1,*, Boudahri2, F., Betaouaf H.2023-05-282023-05-282020-01-01R. Boukli-Hacene1,*, F. Boudahri2, H. Betaouaf. OPTIMAL DESIGN OF PHAREMACEUTICALS SUPPLY CHAIN. Journal of Fundamental and sciences. vol.10, no 2. May 2018. Faculty of exact sciences. university of el oued. [visited in 01/05/2018. available from [copy the link here]http://dspace.univ-eloued.dz/handle/123456789/24407articalt is very known that the availability of drugs is the major problem faced by patients. Therefore, this article deals with the optimization of a pharmaceutical supply chain, i.e. we need to reorganize the entire current pharmaceutical network with a main objective of no patient suffers as long as the medicine exists somewhere. Achieving this requires a strategic organization of the geographic network in order to gain a better distribution. It is based on the information that must be received after a general study on the entire health sector in a specific area. The problem is formulated in a nonlinear model (MINLP) and in order to solve it we resort to using optimization solvers to show the effectiveness of this approachenSupply chain; optimization; medicines; pharmaceutical network; distribution.Article