همامي, هادية2019-05-082019-05-082017-03-16https://dspace.univ-eloued.dz/handle/123456789/97Thèse en vue de l’obtention du diplôme de doctorat en chimie Spécialité : Electrochimie analytique et environnementIn this work we synthesized a series of N-(ferrocenylmethyl) nitroaniline starting from the quaternary salt ferrocenylmethyltrimethylammonium iodide and the corresponding nitoraniline, the obtained products were acylated using different acylating reagents. All obtained derivatives were characterised by usual spectroscopic and electrochemical techniques. The antioxidant activity of synthesized compounds were evaluated using electrochemical and spectrophotochemical methods, in the former the superoxyde anion radicals were used and in the later 1,1-diphenyl-2-picrylhydrazyl - DPPH - radicals were used. The free bending energy between the two radicals and the studied potential antioxidant compounds were determined from electrochemical and spectrophotochemical data. In addition the antimutagenic activity was evaluated by studding the interaction between deoxyribonucleic acid and the synthesized derivatives, also the binding parameters such as free binding energy and ratio of binding constant were calculated from electrochemical data and validated by electronic spectroscopy. The bending sites sizes of bounded derivatives with deoxyribonucleic acid were calculated from cyclic voltametry experiments. To further confirm the interaction between deoxyribonucleic acid and the synthesized derivatives the coefficient diffusion of free and bounded forms of the compounds with deoxyribonucleic acid was calculated from electrochemical data. Keywords: ferrocene derivatives, antioxidant activities, antimutagenic activity, superoxide anion radical, DPPH, binding parameters, cyclic voltammetry, coefficient diffusion.enferrocene derivatives, antioxidant activities, antimutagenic activity, superoxide anion radical, DPPH, binding parameters, cyclic voltammetry, coefficient diffusion.المشتقات الفيروسينية, الفعالية المضادة للاكسدة, الفعالية المضادة للتطفر, جذر الاكسجين النشط, جذر ثنائي فينيل بكريل هايدرازيل الفولطاأمبيرومتري الحلقي, الطاقة الحرة للترابط, معامل الانتشار, ثابت الترابطThesis