Faculty of natural and life science_PPI

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Browsing Faculty of natural and life science_PPI by Author "Derouiche, Samir"

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    Biological properties and Acute Toxicity Study of Copper oxide nanoparticles prepared by aqueous leaves extract of Portulaca oleracea
    (A & V Publications, 2020-06-03) Atoussi, Ouidad; Chetehouna, Sara; Derouiche, Samir
    The aim of this study is to use the purslan (Portulacae oleracea L) leaves aqueous extract in order to prepare copper nanoparticles and to explore antioxidant and anti-inflammatory activity of aqueous extract of P.oleracea L and CuNPs. The nanoparticles were characterized from structural and morphological point of view by using analytical techniques such as: UV-Vis spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), and Scanning Electron Microscopy (SEM). Antioxidant activity of purslane and CuNPs was studied done FRAP assay also the anti-inflammatory and hemolysis essay were studies. The acute toxicity test was applied in Wistar albino rats. Obtain results show that the SEM analysis revealed that the particle size was found to be ranging under 46 nm. On the other hand, the copper nanoparticles and purslan possessed the reducing capacity when IC50 value was 68, 316 μg/ml and 79, 675 μg/ml respectively, the anti-inflammatory ability while IC50 value was 77, 503 μg/ml and 60, 727 μg/ml respectively. In this study, the toxicity test showed no mortality or behavioral change up to 20 mg/kg of albino Wistar rats CuNPs. We concluded that Portulaca oleracea L has potential properties as biocatalyst or natural stabilizers for CuNPs synthesis. Each CuNPs as P.oleracea L leaves extract were have a reducing and anti-inflammatory capacity which can be protect the cells against the degenerative effects of Reactive Oxygen Species (ROS).
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    Current Review on Herbal Pharmaceutical improve immune responses against COVID-19 infection
    (A&V Publications, 2020-07-01) Derouiche, Samir
    Coronavirus SARS-COV2 (COVID-19) represents the causative agent of a potentially fatal disease that is of great global public health concern. The pandemic outbreak of COVID-19 is rapidly spreading all over the world. This review aims to provide the role of Herbal Pharmaceutical in reducing the spread or complications of COVID-19 infection in the body of people. The evidence of generation of oxygen free radicals and oxidative stress is a key process in the onset of chronic disease which participate in the development of the systemic inflammatory response syndrome. Medicines of plant origin aroused a lot of interest due to their wide use, abundance, high efficacy and lack of secondary effects as an antioxidants and anti-inflammatory agents, antiviral efficacy or in their preventive efficacy of the immune system From it we suggest that the combination of conventional therapy and herbal medicine for patients infected with COVID-19 to reduce the complexities and development of the virus
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    Oxidative Stress Associated with SARS-Cov-2 (COVID-19) Increases the Severity of the Lung Disease - A Systematic Review
    (Journal of Infectious Diseases and Epidemiology, 2020-05-04) Derouiche, Samir
    COVID-19 patients have a higher risk of developing inflammatory responses associated with serious and even fatal respiratory diseases. This review focuses on the relationship between oxidative stress and COVID-19. Coronaviruses are a family of common RNA viruses that can cause serious lower respiratory tract infections, followed by bronchitis and pneumonia. Pulmonary inflammation, fever and fibrosis are symptoms of COVID-19 mediated by cytokine pro-inflammatory. Oxidative stress affect repair mechanisms and the immune control system, which is one of the main events of the inflammatory response which allows us also to conclude that oxidative stress is a major factor increasing the severity of COVID-19 especially during chronic diseases associated with the fragility of the antioxidant system, suggesting to recommend antioxidants supplementation in therapeutic strategies against COVID-19.
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    STUDY OF FLUORIDE-INDUCED HAEMATOLOGICAL ALTERATIONS AND LIVER OXIDATIVE STRESS IN RATS
    (WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 2017-05) Djouadi, Anfal; Derouiche, Samir
    Fluorine is a necessary biological trace element for human health. However, fluoride accumulation leads to cascading effects resulting in altered physiological functions in human being. The current studies evaluated the effect of fluoride induced hematological alterations and oxidative stress in the liver of experimental rats. For this purpose, adult female Wistar albino rats divided into control and NaF treated group. sodium Fluoride (400 mg/kg b.w) added in their drinking water for 70 days. Compared with the control, a significant decrease in the body weight gain (p<0.001) and increase in relative liver weight (p<0.001) were noticed in the NaF group Our results showed that fluoride treatment caused a increase in Granulocyte (p < 0.001), White blood cell (p < 0.001), Lymphocyte (p < 0.01) and Platelets (p < 0.01) compared with the control. In addition, it led to an increases in triglyceride (p<0.001), cholesterol (p<0.01) level, GOT (p<0.01) and GPT (p<0.001) activities in serum animal compared to the control group . In contrast fluoride caused an oxidative stress by decrease in GSH level and GST activity and increase in MDA concentration compared with the control group. In Conclusion, Results demonstrated the toxic effect of high-dose of fluoride by causing oxidative stress and inflammation in hepatic tissue.
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    Study of oxidative stress during pregnancy
    (Juniper Publishers, 2017-10-10) Derouiche, Samir; Doudi, Dalal; Atia, Noura
    Oxidative stress is defined as an imbalance in the balance between antioxidants and pro-oxidants in favor of antioxidants. The increase in lipid peroxidation and the significant decrease in GSH and total antioxidant power ORAC in the serum and erythrocytes of pregnant women especially during the third trimester of pregnancy clearly show the evolution of the state of stress oxidative therapy associated with pregnancy in pregnant women. So pregnancy is a physiological state characterized by oxidative disturbance that contributes to the initiation and progression of complications associated with pregnancy