Investigation of renal toxicity induced by neonicotinoid (thiamethoxam) insecticide in mice
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Date
2018-12-01
Journal Title
Journal ISSN
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Publisher
University of Eloued جامعة الوادي
Abstract
The investigation of the toxicity of a neonicotinoid insecticide, thiamethoxam, in mammals has been the
subject of several experimental studies. In the present work, we are particularly interested in studying the
renal toxic effects of two doses (0.2 and 0.4 mg/kg/day) of thiamethoxam, an insecticide widely marketed in
Algeria, administered orally in adult male mice. For this purpose, a renal histopathological study and plasma
assays of the uremia and the creatinemia are carried out. Examination of the histological sections recorded
dose-dependent lesions in the renal parenchyma. Renal impairment is characterized by the destruction of
certain glomeruli and the presence of some hemorrhagic and inflammatory foci. These alterations are
associated with leukocyte diapedesis presented in the blood vessels. The renal function is maintained in the
normal state because the urea and creatinine contents remain unchanged. On the basis of these results, it turns
out that thiamethoxam treatment induces a dose-dependent renal toxicity in male mice.
Description
Articale in International Journal of biological and Agricultural Research Vol. 01 N. 02
Keywords
Renal Function; Histopathology; Adult male mice; Thiamethoxam; Toxicity; Dose-dependent
Citation
Articale in International Journal of biological and Agricultural Research Vol. 01 N. 02